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Portable Biosensors and Point-of-Care Systems [Hardback]

Edited by (Agricultural University of Athens, Greece)
  • Formāts: Hardback, 384 pages, height x width: 234x156 mm
  • Sērija : Healthcare Technologies
  • Izdošanas datums: 10-Feb-2017
  • Izdevniecība: Institution of Engineering and Technology
  • ISBN-10: 1849199620
  • ISBN-13: 9781849199629
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Portable Biosensors and Point-of-Care SystemsPalielināt
  • Formāts: Hardback, 384 pages, height x width: 234x156 mm
  • Sērija : Healthcare Technologies
  • Izdošanas datums: 10-Feb-2017
  • Izdevniecība: Institution of Engineering and Technology
  • ISBN-10: 1849199620
  • ISBN-13: 9781849199629
Citas grāmatas par šo tēmu:
Permanent link: https://www.kriso.lv/db/9781849199629.html
Keywords:
Portable Biosensors and Point-of-Care Systems describes the principles, design and applications of a new generation of analytical and diagnostic biomedical devices, characterized by their very small size, ease of use, multi-analytical capabilities and speed to provide handheld and mobile point-of-care (POC) diagnostics.



The book is divided in four Parts. Part I is an in-depth analysis of the various technologies upon which portable diagnostic devices and biosensors are built. In Part II, advances in the design and optimization of special components of biosensor systems and handheld devices are presented. In Part III, a wide scope of applications of portable biosensors and handheld POC devices is described, ranging from the support of primary healthcare to food and environmental safety screening. Diverse topics are covered, including counterterrorism, travel medicine and drug development. Finally, Part IV of the book is dedicated to the presentation of commercially available products including a review of the products of point-of-care in-vitro-diagnostics companies, a review of technologies which have achieved a high Technology Readiness Level, and a special market case study of POC infusion systems combined with intelligent patient monitoring.



This book is essential reading for researchers and experts in the healthcare diagnostic and analytical sector, and for electronics and material engineers working on portable sensors.
List of contributors
xiii
Preface: Beyond the tricorder xvii
Part I Background science and technology
1(126)
1 Portable optical detectors for point-of-care diagnostics
3(24)
Reuven Rasooly
Hugh Alan Bruck
Joshua Balsam
Avraham Rasooly
1.1 Introduction
3(4)
1.1.1 Medical applications for POCT
3(1)
1.1.2 Portable technologies for POCT
4(1)
1.1.3 Optical detection and analysis
4(1)
1.1.4 Examples for the broader use of optical detection in medicine
5(1)
1.1.5 Smartphone and webcam-based POCT
6(1)
1.2 Portable CMOS and CCD imaging-based detection technologies
7(4)
1.2.1 POCT bioassay for foodborne toxins
7(1)
1.2.2 Webcam-based fluorescence plate reader for POCT of foodborne toxins
8(1)
1.2.3 Fluorescence detection of Stx2 activity
9(2)
1.2.4 Application of the webcam-based fluorescence plate reader to other food bone toxins
11(1)
1.3 Computational enhancement of the sensitivity of webcam-based detectors
11(2)
1.3.1 Image stacking-based computational signal enhancement
11(2)
1.4 Capillary arrays as waveguides for enhancing the sensitivity of optical detectors
13(2)
1.4.1 Webcam detector with capillary array
14(1)
1.4.2 Fluorescein detection using capillary array
15(1)
1.5 Smartphone-based fluorescence detection system using capillary array
15(2)
1.5.1 Smartphone-based capillary array fluorescence detector
15(2)
1.5.2 Orthographic optical configuration
17(1)
1.6 Summary of factors contributing to the sensitivity of low-cost optical detectors
17(1)
1.7 Conclusions
18(9)
Acknowledgment
18(1)
References
19(8)
2 Paper-based diagnostic devices
27(20)
Spencer A. Schultz
Isabelle C. Noxon
Tyler A. Sisley
Andres W. Martinez
2.1 Introduction
27(2)
2.2 Current paper-based diagnostic devices
29(4)
2.2.1 Dipstick devices
29(1)
2.2.2 Lateral-flow devices
30(3)
2.2.3 Paper-based arrays
33(1)
2.3 Paper-based microfluidic devices
33(7)
2.3.1 Fabrication of paper-based microfluidic devices
34(3)
2.3.2 Applications of paper-based microfluidic devices
37(3)
2.4 Conclusions
40(7)
References
41(6)
3 Advanced lateral flow technology for point-of-care and field-based applications
47(26)
Brendan O'Farrell
3.1 Introduction
47(2)
3.1.1 Advantages of lateral-flow assay systems
47(1)
3.1.2 The S-curve and lateral flow
48(1)
3.2 Lateral-flow assays from first principles: key elements of a high performance lateral-flow assay system
49(21)
3.2.1 Lateral-flow assay architecture and formats---a brief introduction
50(2)
3.2.2 Device design
52(9)
3.2.3 User-centered design of devices for field-based applications
61(9)
3.3 Conclusion
70(3)
Reference
71(2)
4 Point-of-care electrochemical sensors for antibody detection
73(10)
Robert L. Rubin
Konstantin N. Konstantinov
4.1 Introduction
73(1)
4.2 Challenges in antibody measurement by POC technology
74(1)
4.3 Detection of antibody utilizing electrochemical methodology
75(3)
4.4 Electrochemical biosensors for specific antibody with potential as POC instruments
78(1)
4.5 Perspectives on future development of POC devices for antibody measurement
79(4)
References
80(3)
5 Portable magnetoelastic biosensors
83(26)
Howard C. Wikle
Bryan A. Chin
5.1 Introduction
83(7)
5.1.1 Magnetostriction and magnetoelastic coupling
84(2)
5.1.2 Magnetostrictive ribbons
86(2)
5.1.3 Magnetostrictive microcantilevers
88(1)
5.1.4 Comparison to other AW devices
89(1)
5.2 ME biosensors
90(5)
5.2.1 Commercially available magnetostrictive ribbons
90(1)
5.2.2 Microfabrication
91(1)
5.2.3 Biomolecular recognition element
92(3)
5.3 Measurement techniques
95(5)
5.3.1 Swept frequency measurement technique
96(1)
5.3.2 Transient response measurement technique
97(2)
5.3.3 Flat coil measurement technique
99(1)
5.4 Additional results
100(4)
5.4.1 Detection in the presence of masking bacteria
100(1)
5.4.2 Detection in liquid foods
101(3)
5.5 Outlook
104(5)
References
104(5)
6 Portable and handheld cell-based biosensors
109(18)
Spyridon E. Kintzios
6.1 Introduction
109(1)
6.2 Designer cells: better than nature?
109(3)
6.3 Cell-based toxicity biosensors
112(15)
References
120(7)
Part II Sub-component design and optimization
127(54)
7 Novel nanocomposite materials for miniaturized biosensor fabrication
129(12)
G. Roussos
N. Chaniotakis
7.1 Introduction
129(1)
7.2 Principles of biosensors
130(1)
7.3 Miniaturization of biosensors
131(1)
7.4 Nanocomposite materials
132(3)
7.4.1 Application of carbon nanocomposites in biosensor optimization
133(2)
7.5 Future trends
135(6)
References
137(4)
8 Monolithically integrated optoelectronic biosensors for point-of-need applications
141(28)
Panagiota Petrou
Eleni Makarona
Ioannis Raptis
Konstantinos Misiakos
Sotirios Kakabakos
8.1 Introduction
141(3)
8.2 Integrated optical sensors
144(10)
8.2.1 Grating-coupled waveguide sensors
144(2)
8.2.2 Microring resonators
146(2)
8.2.3 Photonic crystal waveguides
148(2)
8.2.4 Integrated interferometers
150(3)
8.2.5 Silicon nanowires, slot waveguides and other sensor configurations
153(1)
8.3 Monolithically integrated optoelectronic transducers
154(4)
8.4 Conclusion and outlook
158(11)
References
159(10)
9 Time-series processing for portable biosensors and mobile platforms for automated pattern recognition
169(12)
C.P. Yialouris
K.P. Ferentinos
9.1 Introduction
169(1)
9.2 Time-series analysis
170(1)
9.3 Extracting features from time-series created by biosensors for pattern recognition
171(3)
9.3.1 Pattern recognition
172(1)
9.3.2 Resampling
173(1)
9.3.3 Fixed segmentation
173(1)
9.3.4 Feature extraction with genetic algorithms support
173(1)
9.4 Portable biosensors using Smartphone capabilities
174(2)
9.5 Conclusion
176(5)
References
177(4)
Part III Applications
181(72)
10 Nanosensors in food safety
183(26)
Preetam Sarkar
Shubham Subrot Panigrahi
Emily Roy
Pratik Banerjee
10.1 Introduction
183(2)
10.1.1 Food safety: global public health concern
183(1)
10.1.2 Food safety: a challenging field for nanotechnological innovations
184(1)
10.2 Nanosensors
185(14)
10.2.1 Optical nanosensors
186(6)
10.2.2 Biosensors and biological nanosensors
192(2)
10.2.3 Nanotechnology-based biosensors
194(5)
10.3 Concluding remarks
199(10)
References
200(9)
11 POC in biowarfare detection and defence applications: an update
209(22)
Petr Skladal
11.1 Introduction
209(1)
11.2 Biodetection technologies
210(10)
11.2.1 Paper and lateral-flow-based assays
210(1)
11.2.2 Microfluidic and lab-on-chip concepts
210(3)
11.2.3 Electrochemical biosensors
213(1)
11.2.4 DNA analysis on chips
213(3)
11.2.5 Smartphones for analysis
216(1)
11.2.6 Surface plasmon resonance based approaches
217(1)
11.2.7 Bioaerosols
217(3)
11.3 Target microbes and other bioagents
220(5)
11.3.1 Bacteria
220(1)
11.3.2 Viruses
221(3)
11.3.3 Toxins
224(1)
11.3.4 Antimicrobial antibodies
224(1)
11.4 Conclusion
225(6)
References
226(5)
12 POC in travel, marine, and airport security monitoring
231(8)
M. Drancourt
12.1 Introduction
231(1)
12.2 Remote detection of fever in travelers
232(1)
12.3 Documented infections during mass plane traveling
232(1)
12.4 Documented infections during cruise ship traveling
233(1)
12.5 Proposed management of febrile patients in airport and cruise facilities
233(1)
12.6 Setting-up POC diagnosis in airports and travel facilities
234(1)
12.7 Perspectives
235(1)
12.8 Conflicts of interest
235(4)
References
236(3)
13 Biosensor applications in veterinary science
239(14)
Georgia Moschopoulou
13.1 Introduction
239(1)
13.2 Biosensors in animal husbandry
239(6)
13.2.1 Disease surveillance
239(5)
13.2.2 Estrus and fertility monitoring
244(1)
13.2.3 Other applications
244(1)
13.3 Biosensors in pet care
245(1)
13.3.1 Glucose and lactate monitoring
245(1)
13.3.2 Screening for infectious disease
245(1)
13.4 Conclusion
246(7)
References
246(7)
Part IV Commercialization
253(90)
14 Commercialized point-of-care technologies
255(54)
G. P. Kanakaris
C. Sotiropoulos
L.G. Alexopoulos
14.1 Introduction
255(1)
14.2 Commercialized point-of-care systems---technology categorization
256(24)
14.2.1 Lateral-flow assays
256(9)
14.2.2 Centrifugal point-of-care systems
265(5)
14.2.3 Electrochemical sensing systems
270(5)
14.2.4 Nucleic acid testing systems
275(2)
14.2.5 Blood gas/electrolyte benchtop systems
277(1)
14.2.6 Other technologies
278(2)
14.3 Commercialized point-of-care systems---biomarkers
280(18)
14.4 Conclusions
298(11)
References
299(10)
15 Consumer diagnostics
309(24)
Spyridon E. Kintzios
15.1 Introduction
309(1)
15.2 Improvements in working principles/assay concepts
309(6)
15.2.1 Breath analysis biosensors
309(2)
15.2.2 Electrochemical and bioelectrical sensors
311(1)
15.2.3 Optical biosensors
312(1)
15.2.4 DNA nanotechnology-based sensors
312(2)
15.2.5 Ultraminiaturized and endoscopic biosensors
314(1)
15.3 Recent examples of commercial biosensors
315(18)
15.3.1 Food safety analysis
315(3)
15.3.2 Glucose sensors
318(1)
15.3.3 Cholesterol sensors
318(1)
15.3.4 Wearable POC systems
319(1)
15.3.5 Niche consumer diagnostic POC/POT systems
320(2)
References
322(11)
16 A market case report: point-of-care infusion management and intelligent patient monitoring
333(10)
Alexandre Tsoukalis
16.1 Infusion and infusion management at point-of-care today
333(1)
16.2 Infusion pump basics
333(5)
16.3 Infusion `smart pumps'
338(1)
16.4 Problems of infusion pumps at point of care
339(1)
16.5 Micrel Medical Devices patented innovation solving problems at point of care
339(4)
References
342(1)
Index 343
Spyridon E. Kintzios is Dean of the School of Food Science, Biotechnology and Development, Agricultural University of Athens, Greece and Director of the Laboratory of Cell Technology. He received his PhD from the Technical University of Munich. He has worked for over 25 years in Biotechnology, particularly in the fields of Biosensors and Cell Biology. He is the inventor of the Bioelectric Recognition Assay (BERA) and the technology of Molecular Identification through Membrane Engineering (MIME). He has authored approximately 100 original research publications in international journals.