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xiii | |
Preface: Beyond the tricorder |
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xvii | |
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Part I Background science and technology |
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1 | (126) |
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1 Portable optical detectors for point-of-care diagnostics |
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3 | (24) |
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3 | (4) |
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1.1.1 Medical applications for POCT |
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3 | (1) |
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1.1.2 Portable technologies for POCT |
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4 | (1) |
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1.1.3 Optical detection and analysis |
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4 | (1) |
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1.1.4 Examples for the broader use of optical detection in medicine |
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5 | (1) |
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1.1.5 Smartphone and webcam-based POCT |
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6 | (1) |
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1.2 Portable CMOS and CCD imaging-based detection technologies |
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7 | (4) |
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1.2.1 POCT bioassay for foodborne toxins |
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7 | (1) |
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1.2.2 Webcam-based fluorescence plate reader for POCT of foodborne toxins |
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8 | (1) |
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1.2.3 Fluorescence detection of Stx2 activity |
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9 | (2) |
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1.2.4 Application of the webcam-based fluorescence plate reader to other food bone toxins |
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11 | (1) |
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1.3 Computational enhancement of the sensitivity of webcam-based detectors |
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11 | (2) |
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1.3.1 Image stacking-based computational signal enhancement |
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11 | (2) |
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1.4 Capillary arrays as waveguides for enhancing the sensitivity of optical detectors |
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13 | (2) |
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1.4.1 Webcam detector with capillary array |
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14 | (1) |
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1.4.2 Fluorescein detection using capillary array |
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15 | (1) |
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1.5 Smartphone-based fluorescence detection system using capillary array |
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15 | (2) |
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1.5.1 Smartphone-based capillary array fluorescence detector |
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15 | (2) |
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1.5.2 Orthographic optical configuration |
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17 | (1) |
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1.6 Summary of factors contributing to the sensitivity of low-cost optical detectors |
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17 | (1) |
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18 | (9) |
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18 | (1) |
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19 | (8) |
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2 Paper-based diagnostic devices |
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27 | (20) |
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27 | (2) |
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2.2 Current paper-based diagnostic devices |
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29 | (4) |
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29 | (1) |
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2.2.2 Lateral-flow devices |
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30 | (3) |
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33 | (1) |
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2.3 Paper-based microfluidic devices |
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33 | (7) |
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2.3.1 Fabrication of paper-based microfluidic devices |
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34 | (3) |
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2.3.2 Applications of paper-based microfluidic devices |
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37 | (3) |
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40 | (7) |
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41 | (6) |
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3 Advanced lateral flow technology for point-of-care and field-based applications |
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47 | (26) |
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47 | (2) |
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3.1.1 Advantages of lateral-flow assay systems |
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47 | (1) |
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3.1.2 The S-curve and lateral flow |
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48 | (1) |
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3.2 Lateral-flow assays from first principles: key elements of a high performance lateral-flow assay system |
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49 | (21) |
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3.2.1 Lateral-flow assay architecture and formats---a brief introduction |
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50 | (2) |
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52 | (9) |
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3.2.3 User-centered design of devices for field-based applications |
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61 | (9) |
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70 | (3) |
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71 | (2) |
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4 Point-of-care electrochemical sensors for antibody detection |
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73 | (10) |
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Konstantin N. Konstantinov |
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73 | (1) |
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4.2 Challenges in antibody measurement by POC technology |
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74 | (1) |
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4.3 Detection of antibody utilizing electrochemical methodology |
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75 | (3) |
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4.4 Electrochemical biosensors for specific antibody with potential as POC instruments |
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78 | (1) |
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4.5 Perspectives on future development of POC devices for antibody measurement |
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79 | (4) |
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80 | (3) |
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5 Portable magnetoelastic biosensors |
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83 | (26) |
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83 | (7) |
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5.1.1 Magnetostriction and magnetoelastic coupling |
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84 | (2) |
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5.1.2 Magnetostrictive ribbons |
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86 | (2) |
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5.1.3 Magnetostrictive microcantilevers |
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88 | (1) |
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5.1.4 Comparison to other AW devices |
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89 | (1) |
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90 | (5) |
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5.2.1 Commercially available magnetostrictive ribbons |
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90 | (1) |
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91 | (1) |
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5.2.3 Biomolecular recognition element |
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92 | (3) |
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5.3 Measurement techniques |
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95 | (5) |
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5.3.1 Swept frequency measurement technique |
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96 | (1) |
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5.3.2 Transient response measurement technique |
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97 | (2) |
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5.3.3 Flat coil measurement technique |
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99 | (1) |
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100 | (4) |
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5.4.1 Detection in the presence of masking bacteria |
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100 | (1) |
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5.4.2 Detection in liquid foods |
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101 | (3) |
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104 | (5) |
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104 | (5) |
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6 Portable and handheld cell-based biosensors |
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109 | (18) |
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109 | (1) |
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6.2 Designer cells: better than nature? |
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109 | (3) |
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6.3 Cell-based toxicity biosensors |
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112 | (15) |
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120 | (7) |
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Part II Sub-component design and optimization |
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127 | (54) |
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7 Novel nanocomposite materials for miniaturized biosensor fabrication |
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129 | (12) |
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129 | (1) |
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7.2 Principles of biosensors |
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130 | (1) |
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7.3 Miniaturization of biosensors |
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131 | (1) |
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7.4 Nanocomposite materials |
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132 | (3) |
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7.4.1 Application of carbon nanocomposites in biosensor optimization |
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133 | (2) |
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135 | (6) |
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137 | (4) |
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8 Monolithically integrated optoelectronic biosensors for point-of-need applications |
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141 | (28) |
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141 | (3) |
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8.2 Integrated optical sensors |
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144 | (10) |
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8.2.1 Grating-coupled waveguide sensors |
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144 | (2) |
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8.2.2 Microring resonators |
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146 | (2) |
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8.2.3 Photonic crystal waveguides |
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148 | (2) |
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8.2.4 Integrated interferometers |
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150 | (3) |
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8.2.5 Silicon nanowires, slot waveguides and other sensor configurations |
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153 | (1) |
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8.3 Monolithically integrated optoelectronic transducers |
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154 | (4) |
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8.4 Conclusion and outlook |
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158 | (11) |
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159 | (10) |
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9 Time-series processing for portable biosensors and mobile platforms for automated pattern recognition |
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169 | (12) |
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169 | (1) |
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170 | (1) |
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9.3 Extracting features from time-series created by biosensors for pattern recognition |
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171 | (3) |
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9.3.1 Pattern recognition |
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172 | (1) |
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173 | (1) |
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173 | (1) |
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9.3.4 Feature extraction with genetic algorithms support |
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173 | (1) |
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9.4 Portable biosensors using Smartphone capabilities |
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174 | (2) |
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176 | (5) |
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177 | (4) |
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181 | (72) |
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10 Nanosensors in food safety |
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183 | (26) |
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183 | (2) |
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10.1.1 Food safety: global public health concern |
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183 | (1) |
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10.1.2 Food safety: a challenging field for nanotechnological innovations |
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184 | (1) |
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185 | (14) |
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10.2.1 Optical nanosensors |
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186 | (6) |
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10.2.2 Biosensors and biological nanosensors |
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192 | (2) |
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10.2.3 Nanotechnology-based biosensors |
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194 | (5) |
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199 | (10) |
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200 | (9) |
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11 POC in biowarfare detection and defence applications: an update |
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209 | (22) |
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209 | (1) |
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11.2 Biodetection technologies |
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210 | (10) |
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11.2.1 Paper and lateral-flow-based assays |
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210 | (1) |
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11.2.2 Microfluidic and lab-on-chip concepts |
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210 | (3) |
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11.2.3 Electrochemical biosensors |
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213 | (1) |
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11.2.4 DNA analysis on chips |
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213 | (3) |
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11.2.5 Smartphones for analysis |
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216 | (1) |
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11.2.6 Surface plasmon resonance based approaches |
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217 | (1) |
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217 | (3) |
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11.3 Target microbes and other bioagents |
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220 | (5) |
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220 | (1) |
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221 | (3) |
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224 | (1) |
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11.3.4 Antimicrobial antibodies |
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224 | (1) |
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225 | (6) |
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226 | (5) |
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12 POC in travel, marine, and airport security monitoring |
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231 | (8) |
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231 | (1) |
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12.2 Remote detection of fever in travelers |
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232 | (1) |
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12.3 Documented infections during mass plane traveling |
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232 | (1) |
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12.4 Documented infections during cruise ship traveling |
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233 | (1) |
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12.5 Proposed management of febrile patients in airport and cruise facilities |
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233 | (1) |
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12.6 Setting-up POC diagnosis in airports and travel facilities |
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234 | (1) |
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235 | (1) |
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12.8 Conflicts of interest |
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235 | (4) |
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236 | (3) |
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13 Biosensor applications in veterinary science |
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239 | (14) |
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239 | (1) |
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13.2 Biosensors in animal husbandry |
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239 | (6) |
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13.2.1 Disease surveillance |
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239 | (5) |
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13.2.2 Estrus and fertility monitoring |
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244 | (1) |
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13.2.3 Other applications |
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244 | (1) |
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13.3 Biosensors in pet care |
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245 | (1) |
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13.3.1 Glucose and lactate monitoring |
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245 | (1) |
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13.3.2 Screening for infectious disease |
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245 | (1) |
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246 | (7) |
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246 | (7) |
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Part IV Commercialization |
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253 | (90) |
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14 Commercialized point-of-care technologies |
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255 | (54) |
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255 | (1) |
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14.2 Commercialized point-of-care systems---technology categorization |
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256 | (24) |
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14.2.1 Lateral-flow assays |
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256 | (9) |
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14.2.2 Centrifugal point-of-care systems |
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265 | (5) |
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14.2.3 Electrochemical sensing systems |
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270 | (5) |
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14.2.4 Nucleic acid testing systems |
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275 | (2) |
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14.2.5 Blood gas/electrolyte benchtop systems |
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277 | (1) |
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14.2.6 Other technologies |
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278 | (2) |
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14.3 Commercialized point-of-care systems---biomarkers |
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280 | (18) |
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298 | (11) |
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299 | (10) |
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309 | (24) |
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309 | (1) |
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15.2 Improvements in working principles/assay concepts |
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309 | (6) |
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15.2.1 Breath analysis biosensors |
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309 | (2) |
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15.2.2 Electrochemical and bioelectrical sensors |
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311 | (1) |
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15.2.3 Optical biosensors |
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312 | (1) |
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15.2.4 DNA nanotechnology-based sensors |
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312 | (2) |
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15.2.5 Ultraminiaturized and endoscopic biosensors |
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314 | (1) |
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15.3 Recent examples of commercial biosensors |
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315 | (18) |
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15.3.1 Food safety analysis |
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315 | (3) |
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318 | (1) |
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15.3.3 Cholesterol sensors |
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318 | (1) |
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15.3.4 Wearable POC systems |
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319 | (1) |
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15.3.5 Niche consumer diagnostic POC/POT systems |
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320 | (2) |
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322 | (11) |
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16 A market case report: point-of-care infusion management and intelligent patient monitoring |
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333 | (10) |
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16.1 Infusion and infusion management at point-of-care today |
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333 | (1) |
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16.2 Infusion pump basics |
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333 | (5) |
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16.3 Infusion `smart pumps' |
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338 | (1) |
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16.4 Problems of infusion pumps at point of care |
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339 | (1) |
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16.5 Micrel Medical Devices patented innovation solving problems at point of care |
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339 | (4) |
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342 | (1) |
Index |
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343 | |