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Tumor Models in Cancer Research Second Edition 2011 [Hardback]

  • Formāts: Hardback, 693 pages, height x width: 235x155 mm, weight: 1286 g, XIV, 693 p., 1 Hardback
  • Sērija : Cancer Drug Discovery and Development
  • Izdošanas datums: 02-Dec-2010
  • Izdevniecība: Humana Press Inc.
  • ISBN-10: 1607619679
  • ISBN-13: 9781607619673
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  • Formāts: Hardback, 693 pages, height x width: 235x155 mm, weight: 1286 g, XIV, 693 p., 1 Hardback
  • Sērija : Cancer Drug Discovery and Development
  • Izdošanas datums: 02-Dec-2010
  • Izdevniecība: Humana Press Inc.
  • ISBN-10: 1607619679
  • ISBN-13: 9781607619673
Citas grāmatas par šo tēmu:

Since the first edition of this book there has been great progress in the development of genetically engineered mouse (GEM) models of cancer. This revised and updated edition comprehensively describes the state-of-the-art in animal tumor model research.



The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some with multiple genetic changes providing mouse models that are moving closer to the human disease.
Part I Introduction
1 Perspectives on the History and Evolution of Tumor Models
3(20)
Shannon Decker
Edward Sausville
Part II Transplantable Syngeneic Rodent Tumors
2 Murine L1210 and P388 Leukemias
23(20)
William R. Waud
3 Transplantable Syngeneic Rodent Tumors: Solid Tumors in Mice
43(36)
Lisa Polin
Thomas H. Corbett
Bill J. Roberts
Alfred J. Lawson
Wilbur R. Leopold III
Kathryn White
Juiwanna Kushner
Stuart Hazeldine
Richard Moore
James Rake
Jerome P. Horwitz
4 B16 Murine Melanoma: Historical Perspective on the Development of a Solid Tumor Model
79(20)
Enrique Alvarez
Part III Human Tumor Xenografts
5 Human Tumor Xenograft Efficacy Models
99(26)
Ming Liu
Daniel Hicklin
6 Imaging the steps of metastasis at the macro and cellular level with fluorescent proteins in real time
125(42)
Robert M. Hoffman
7 Patient-Derived Tumor Models and Explants
167(28)
Heinz-Herbert Fiebig
Angelika M. Burger
8 The Pediatric Preclinical Testing Program
195(20)
Christopher L. Morton
Peter J. Houghton
9 Imaging Efficacy in Tumor Models
215(30)
Vinod Kaimal
Wilbur R. Leopold
Patrick McConville
Part IV Carcinogen-Induced Tumors
10 Mammary Cancer in Rats
245(14)
Henry J. Thompson
Part V Disease and Target-Specific Models
11 Animal Models of Melanoma
259(28)
Ene T. Fairchild
William E. Carson, III
12 Experimental Animal Models for Investigating Renal Cell Carcinoma Pathogenesis and Preclinical Therapeutic Approaches
287(20)
Gilda G. Hillman
13 Animal Models of Mesothelioma
307(18)
Harvey I. Pass
Joseph B. Pincus
Michele Carbone
Magdalena Plasilova
14 The Use of Mouse Models to Study Leukemia/Lymphoma and Assess Therapeutic Approaches
325(28)
William Siders
15 Spontaneous Companion Animal (Pet) Cancers
353(24)
David M. Vail
Douglas H. Thamm
Part VI Genetically Engineered Mouse Models of Cancer
16 Genetically Engineered Mouse Models of Pancreatic Ductal Adenocarcinoma
377(20)
Aram F. Hezel
Nabeel Bardeesy
17 Transgenic Adenocarcinoma of the Mouse Prostate: A Validated Model for the Identification and Characterization of Molecular Targets and The Evaluation of Therapeutic Agents
397(26)
Sharon D. Morgenbesser
18 The Utility of Transgenic Mouse Models for Cancer Prevention Research
423(24)
Stephen D. Hursting
Laura M. Lashinger
Powel H. Brown
Susan N. Perkins
Part VII Metastasis Models
19 Models for Evaluation of Targeted Therapies of Invasive and Metastatic Disease
447(52)
Suzanne A. Eccles
Part VIII Normal Tissue Response Models
20 Animal Models of Toxicities Caused by Anti-Neoplastic Therapy
499(22)
Stephen T. Sonis
Gregory Lyng
Kimberly Pouliot
21 Bone Marrow as a Critical Normal Tissue that Limits Drug Dose/Exposure in Preclinical Models and the Clinic
521(32)
Ralph E. Parchment
22 Anesthetic Considerations for the Study of Murine Tumor Models
553(18)
Thies Schroeder
Siqing Shan
Mark W. Dewhirst
Part IX Experimental Methods and Endpoints
23 Preclinical Tumor Response End Points
571(36)
Beverly A. Teicher
24 Tumor Cell Survival
607(18)
Sara Rockwell
25 Apoptosis In Vivo
625(16)
L.C. Stephens
L. Milas
K.K. Aug
K.A. Mason
R.E. Meyn
26 Transparent Window Models and Intravital Microscopy: Imaging Gene Expression, Physiological Function and Therapeutic Effects in Tumors
641(40)
Rakesh K. Jain
Lance L. Munn
Dai Fukumura
Index 681
Dr. Beverly A. Teicher is Senior Scientific Director in Cancer Research at Genzyme Molecular Oncology and Genzyme Corporation, Framingham, Massachusetts. She has authored or co-authored more than 400 scientific publications, has edited five books, senior editor for the journal Clinical Cancer Research and is series editor for the Cancer Drug Discovery and Development book series.