Since the first edition of this book there has been great progress in the development of genetically engineered mouse (GEM) models of cancer. This revised and updated edition comprehensively describes the state-of-the-art in animal tumor model research.
The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some with multiple genetic changes providing mouse models that are moving closer to the human disease.
TUMOR MODELS IN CANCER RESEARCH2nd editionBeverly A TeicherTable of ContentsINTRODUCTION1. Perspectives on the History and Evolution of Tumor ModelsShannon Decker and Edward SausvilleTRANSPLANTABLE SYNGENEIC RODENT TUMORS2. Murine L1210 and P388 LeukemiasWilliam R Waud3. Transplantable Syngeneic Rodent TumorsLisa Polin, Thomas H. Corbett, Bill J. Roberts, Alfred J. Lawson, Wilbur R. Leopold III, Kathryn White, Juiwanna Kushner, Stuart Hazeldine, Richard Moore, James Rake, and Jerome P. Horwitz4. B16 Murine Melanomas : Historical Perspective on the Development of a Solid Tumor ModelEnrique AlvarezHUMAN TUMOR XENOGRAFTS5. Human Tumor Xenograft Efficacy ModelsMing Liu and Daniel Hicklin6. Imaging the Steps of Metastasis at the Macro and Cellular Level with Fluorescent Proteins in Real TimeRobert M. Hoffman7. Patient-derived Tumor Models and ExplantsHeinz-Herbert Fiebig and Angelika M. Burger8. The Pediatric Preclinical Testing ProgramChristopher L. Morton and Peter J. Houghton9. Imaging Efficacy in Tumor ModelsVinod Kaimal, Wilbur R. Leopold, and Patrick McConvilleCARCINOGEN-INDUCED TUMORS10. Mammary Cancer in RatsHenry J. ThompsonDISEASE AND TARGET-SPECIFIC MODELS11. Animal Models of MelanomaEne T. Fairchild and William E. Carson, III12. Experimental Animal Models for Investigating Renal Cell Carcinoma Pathogenesis and Preclinical Therapeutic ApproachesGilda G. Hillman13. Animal Models of MesotheliomaHarvey I. Pass, Joseph B. Pincus Michele Carbone, and Magdalena Plasilova14. The Use of Mouse Models to Study Leukemi /Lymphoma and Assess Therapeutic ApproachesWilliam Siders15. Spontaneous Companion Animal (Pet) CancersDavid M. Vail and Douglas H. ThammGENETICALLY ENGINEERED MOUSE MODELS OF CANCER16. Genetically Engineered Mouse Models of Pancreatic Ductal AdenocarcinomaAram F. Hezel and Nabeel Bardeesy17. Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP): A Validated Model for the Identification and Characterization of Molecular Targets and the Evaluation of Therapeutic AgentsSharon D. Morgenbesser18. Transgenic Mouse Models for Cancer Prevention ResearchStephen D. Hursting, Laura Lashinger, Powel Brown, Susan N. PerkinsMETASTASIS MODELS19. Models for Evaluation of Targeted Therapies of Invasive and Metastatic DiseaseSuzanne A. EcclesNORMAL TISSUE RESPONSE MODELS20. Animal Models of Toxicities caused by Anti-Neoplastic Therapy Stephen T. Sonis, Gregory Lyng, and Kimberly Pouliot21. Bone Marrow as a Critical Normal Tissue Ralph Parchment22. Anesthetic Considerations for the Study of Murine Tumor ModelsThies Schroeder, Siqing Shan, Mark W. DewhirstEXPERIMENTAL METHODS AND ENDPOINTS23. Preclinical Tumor Response End PointsBeverly A. Teicher24. Tumor Cell SurvivalSra Rockwell25. Apoptosis In VivoL.C. Stephens, Luka Milas, K.K. Ang, Katherine A. Mason, and Raymond E. Meyn26. Transparent Window Models and Intravital Miceoscopy: Imaging Gene Expression, Physiological Function and Therapeutic Effects in TumorsRakesh K. Jain, Lance L. Munn, and Dai Fukumura
Dr. Beverly A. Teicher is Senior Scientific Director in Cancer Research at Genzyme Molecular Oncology and Genzyme Corporation, Framingham, Massachusetts. She has authored or co-authored more than 400 scientific publications, has edited five books, senior editor for the journal Clinical Cancer Research and is series editor for the Cancer Drug Discovery and Development book series.
