This doctoral thesis reports on an innovative data repository offering adaptive metadata management to maximise information sharing and comprehension in multidisciplinary and geographically distributed collaborations. It approaches metadata...Lasīt vairāk
This work establishes linear-scaling density-functional theory (DFT) as a powerful tool for understanding enzyme catalysis, one that can complement quantum mechanics/molecular mechanics (QM/MM) and molecular dynamics simulations. The thesis reviews b...Lasīt vairāk
This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autop...Lasīt vairāk
In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of Afr...Lasīt vairāk
The book describes how the study of a single RNA-binding protein and its interaction sites led to the development of the novel protein occupancy profiling technology that for the first time captured the mRNA sequence space contacted by the ensemble...Lasīt vairāk
The cell cycle is a sequence of biochemical events that are controlled by complex but robust molecular machinery. This enables cells to achieve accurate self-reproduction under a broad range of conditions. Environmental changes are transmitted by mol...Lasīt vairāk
This work establishes linear-scaling density-functional theory (DFT) as a powerful tool for understanding enzyme catalysis, one that can complement quantum mechanics/molecular mechanics (QM/MM) and molecular dynamics simulations. The thesis reviews b...Lasīt vairāk
The work reported in this book represents an excellent example of how creative experimentation and technology development, complemented by computational data analysis, can yield important insights that further our understanding of biological entities...Lasīt vairāk
(Izdošanas datums: 14-Dec-2014, Paperback / softback, Izdevniecība: Springer-Verlag Berlin and Heidelberg GmbH & Co. K, ISBN-13: 9783642438196)
The nature of distributed computation in complex systems has often been described in terms of memory, communication and processing. This thesis presents a complete information-theoretic framework to quantify these operations on information (i.e. info...Lasīt vairāk
The cell cycle is a sequence of biochemical events that are controlled by complex but robust molecular machinery. This enables cells to achieve accurate self-reproduction under a broad range of conditions. Environmental changes are transmitted by mol...Lasīt vairāk
(Izdošanas datums: 06-Nov-2012, Hardback, Izdevniecība: Springer-Verlag Berlin and Heidelberg GmbH & Co. K, ISBN-13: 9783642329517)
The nature of distributed computation in complex systems has often been described in terms of memory, communication and processing. This thesis presents a complete information-theoretic framework to quantify these operations on information (i.e. info...Lasīt vairāk
