This book presents the frontier research of toxicology and health risk assessment of chemicals. First, it provides an overview of the current methods of evaluating safety amounts of chemicals and provides a new aspect of the principle of toxicology. Secondly, it shows recent research where the new method of health risk evaluation is adopted, followed by an integrated health risk assessment of chemicals. Finally, it describes the epigenetic inheritance of chemical impact on health throughout several generations.
Estimating the safety amount of chemicals surrounding our lives is not sufficient for health risk evaluation, particularly for carcinogenic compounds, endocrine disruptors, and nano materials. The author’s group has found a family of chemicals linked to ADHD through animal screening and identified its chemical nature using chemoinformatics methods. Based on these new developments, this book proposes to utilize the biomarker common to those chemicals for health risk assessment, independent of exposure routes and physiological dimensions.
The book appeals to researchers and students in the field of toxicology, health risk assessment, pharmacology, and public health.
Chapter
1. Introduction.
Chapter
2. The safe dose in the utilization of
chemicals.
Chapter
3. Carcinogens.
Chapter
4. Endocrine disruptors.-
Chapter
5. Nanomaterials.
Chapter
6. Epigenetic chemicals.
Chapter
7.
Toward the integrated Health risk assessment of chemicals.
Chapter
8.
Expanded toxicological mechanisms of chemicals.
Chapter
9. Fields and
exposure periods.
Chapter 10. Environmental chemicals as plasticity
disruptors.
Chapter
11. It began with the pharmacological evaluation of
endocrine disruptors.
Chapter
12. Integration of health risk assessment for
various chemicals: Common biomarkers in different exposure routes.
Chapter
13. Toward a dimension-free, pre-emptive, integrated health risk assessment
of chemicals.
Chapter
14. Inheritance of neurological disorders.
Chapter
15. Epigenetics.
Chapter
16. Environmental epigenetics.
Masami Ishido is a Senior Researcher at the National Institute for Environmental Studies in Japan. His research interests lie at the crossroads of micro and macro in vision systems and behavioral genetics.
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